6,195 research outputs found
A model for the accidental catalysis of protein unfolding in vivo
Activated processes such as protein unfolding are highly sensitive to
heterogeneity in the environment. We study a highly simplified model of a
protein in a random heterogeneous environment, a model of the in vivo
environment. It is found that if the heterogeneity is sufficiently large the
total rate of the process is essentially a random variable; this may be the
cause of the species-to-species variability in the rate of prion protein
conversion found by Deleault et al. [Nature, 425 (2003) 717].Comment: 5 pages, 2 figure
Representations of U(1,q) and Constructive Quaternion Tensor Products
The representation theory of the group U(1,q) is discussed in detail because
of its possible application in a quaternion version of the Salam-Weinberg
theory.
As a consequence, from purely group theoretical arguments we demonstrate that
the eigenvalues must be right-eigenvalues and that the only consistent scalar
products are the complex ones. We also define an explicit quaternion tensor
product which leads to a set of additional group representations for integer
``spin''.Comment: 28 pages, Latex, Dipartimento di Fisica, Universita di Lecce
INFN-Sezione di Lecc
Taking Stock of Common Core Math Implementation: Supporting Teachers to Shift Instruction: Insights from the Math in Common 2015 Baseline Survey of Teachers and Administrators
In spring 2015, WestEd administered surveys to understand the perspectives on Common Core State Standards-Mathematics (CCSS-M) implementation of teachers and administrators in eight California school districts participating in the Math in Common (MiC) initiative. From this survey effort, we were able to learn from over 1,000 respondents about some of the initial successes and challenges facing California educators attempting to put in place and support new -- and what some consider revolutionary -- ideas in U.S. mathematics education
`Third' Quantization of Vacuum Einstein Gravity and Free Yang-Mills Theories
Based on the algebraico-categorical (:sheaf-theoretic and sheaf
cohomological) conceptual and technical machinery of Abstract Differential
Geometry, a new, genuinely background spacetime manifold independent, field
quantization scenario for vacuum Einstein gravity and free Yang-Mills theories
is introduced. The scheme is coined `third quantization' and, although it
formally appears to follow a canonical route, it is fully covariant, because it
is an expressly functorial `procedure'. Various current and future Quantum
Gravity research issues are discussed under the light of 3rd-quantization. A
postscript gives a brief account of this author's personal encounters with
Rafael Sorkin and his work.Comment: 43 pages; latest version contributed to a fest-volume celebrating
Rafael Sorkin's 60th birthday (Erratum: in earlier versions I had wrongly
written that the Editor for this volume is Daniele Oriti, with CUP as
publisher. I apologize for the mistake.
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Challenges of ultra large scale integration of biomedical computing systems
The NCRI Informatics Initiative is overseeing the implementation of an informatics
framework for the UK cancer research community. The framework advocates an integrated
multidisciplinary method of working between scientific and medical communities. Key to this
process is community adoption of high quality acquisition, storage, sharing and integration of
diverse data elements to improve knowledge of the causes, prevention and treatment of
cancer. The integration of the complex data and meta-data used by these multiple
communities is a significant challenge and there are technical, resource-based and
sociological issues to be addressed. In this paper we review progress aimed at establishing
the framework and outline key challenges in ultra large scale integration of biomedical
computing systems
Connecting up strategy: are senior strategy directors a missing link?
With companies being exhorted to become more strategically agile and internally connected, this article examines the role of the Senior Strategy Director, the executive tasked specifically with internal strategy. In particular, it explores what they do, what specific capabilities they deploy to enable effective contribution to the company, and in what ways they facilitate the connectedness of strategy. An analysis of multiple interviews over time with Senior Strategy Directors of large companies shows the vital and challenging role these executives play in both shaping, connecting up, and executing strategy. This article identifies the particular capabilities necessary for Senior Strategy Directors to perform their role and shows how it all depends upon their skilful deployment. These findings have significant implications for understanding unfolding micro-processes of strategy in large organizations, for assumptions about the skills and capabilities necessary to be an effective Senior Strategy Director, and for business schools in terms of the content and style of strategy courses they provide
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